Hugh Laurie ... Dr. Gregory House (67 episodes, 2004-2007)

Lisa Edelstein ... Dr. Lisa Cuddy (67 episodes, 2004-2007)

Omar Epps ... Dr. Eric Foreman (67 episodes, 2004-2007)

Robert Sean Leonard ... Dr. James Wilson (67 episodes, 2004-2007)

Jesse Spencer ... Dr. Robert Chase (67 episodes, 2004-2007)

Jennifer Morrison ... Dr. Allison Cameron (66 episodes, 2004-2007)

Bobbin Bergstrom ... Nurse / ... (23 episodes, 2005-2007)

Stephanie Venditto ... Nurse Brenda / ... (11 episodes, 2005-2006)

Sela Ward ... Stacy Warner (9 episodes, 2005-2006)

David Morse ... Michael Tritter (6 episodes, 2006-2007)

Marco Pelaez ... Pharmacist / ... (6 episodes, 2004-2007)

Ron Perkins ... Dr. Simpson (5 episodes, 2005-2007)

Chi McBride ... Edward Vogler (5 episodes, 2005)

Currie Graham ... Mark Warner (4 episodes, 2005-2006)

Ingrid Sanai Buron ... Nurse Bev / ... (4 episodes, 2005-2007)

Hira Ambrosino ... Anesthesiologist / ... (4 episodes, 2005-2007)

Rosemary Garris ... Airline Passenger / ... (4 episodes, 2006)
Kevin Moon ... EMT (3 episodes, 2005-2006)

Scott Michael Campbell ... Joe / ... (2 episodes, 2006)

Leighton Meester ... Ali (2 episodes, 2006)

Kimberly Quinn ... Nurse Wendy (2 episodes, 2006-2007)

Edward Edwards ... Richard / ... (2 episodes, 2006)

America Olivo ... Ingrid (2 episodes, 2005-2006)

Kadeem Hardison ... Howard (2 episodes, 2006-2007)

Robin Tunney ... Rebecca Adler (2 episodes, 2004)

Charles S. Dutton ... Rodney Foreman (2 episodes, 2006-2007)

Andrew Airlie ... Orange Colored Patient (2 episodes, 2004)

Al Espinosa ... Dr. Wells (2 episodes, 2004-2006)

Rekha Sharma ... Melanie Landon (2 episodes, 2004)

Peter Birkenhead ... Vincent (2 episodes, 2006)

Maya Massar ... Asthma Mom (2 episodes, 2004)

A.J. Trauth ... Henry (2 episodes, 2005)

Dylan Basu ... Asthma Boy (2 episodes, 2004)

Kenneth Choi ... Dr. Lim (2 episodes, 2004-2005)

Ava Hughes ... Sydney (2 episodes, 2004)

Deirdre M. Smith ... Carol Moffatt (2 episodes, 2005)

Kenya D. Williamson ... Nurse / ... (2 episodes, 2004-2005)

Michale Ascher ... Egg Salad Lady (2 episodes, 2004)

Farrah Skyler Greye ... Nurse (2 episodes, 2004-2005)

Madison Bauer ... Soap Patient / ... (2 episodes, 2004-2005)

Holly Daniels ... Debbie (2 episodes, 2004-2006)

Amber Matthews ... Nurse / ... (2 episodes, 2004)

Cindy Lu ... Nurse / ... (2 episodes, 2005-2007)

Eamon Hunt ... Neurosurgeon / ... (2 episodes, 2005-2006)

Dorothea Harahan ... EMT (2 episodes, 2006)

Joel Moore ... College Student / ... (2 episodes, 2007)

Aulani Rhea ... Nurse / ... (2 episodes, 2007)

Hope Shapiro ... Patient / ... (2 episodes, 2007)